Psychopharmacology
Recent articles
- Chronic restraint stress–induced depression-like behavior is mediated by upregulation of melanopsin expression in C57BL/6 mice retinaAbstract Background Depression is associated with circadian disturbances in which melanopsin was a key mechanism. Further studies have demonstrated that melanopsin gene variations are associated with some depressive disorders and… Read more »
- Involvement of the serotonergic system in the antidepressant-like effect of 1-(phenylselanyl)-2-(p-tolyl)indolizine in miceAbstract Rationale Depression is a mental disorder that affects approximately 280 million people worldwide. In the search for new treatments for mood disorders, compounds containing selenium and indolizine derivatives show… Read more »
- Does alcohol automatically capture drinkers’ attention? Exploration through an eye-tracking saccadic choice taskAbstract Rationale Dominant theoretical models postulate the presence of an automatic attentional bias (AB) towards alcohol-related stimuli in alcohol use disorder, such AB constituting a core feature of this disorder.… Read more »
- Melatonin alleviates PTSD-like behaviors and restores serum GABA and cortisol levels in miceAbstract Rationale Melatonin is an endogenous hormone which modulates sleep-wake cycles. Previous studies have found a close correlation between melatonin and post-traumatic stress disorder (PTSD), a trauma- and stress-related psychiatric… Read more »
- Unravelling the dorsal periaqueductal grey matter NMDA receptors relevance in the nitric oxide-mediated panic‑like behaviour and defensive antinociception organised by the anterior hypothalamus of male miceAbstract Rationale Previous studies suggested that the dorsal column of the periaqueductal grey matter (dPAG) can be a target of neural pathways from hypothalamic nuclei involved in triggering fear-related defensive… Read more »
- Association between iron accumulation in the dorsal striatum and compulsive drinking in alcohol use disorderAbstract Rationale Brain iron accumulation has been observed in neuropsychiatric disorders and shown to be related to neurodegeneration. Objectives In this study, we used quantitative susceptibility mapping (QSM), an emerging… Read more »
- Serotonin transporter availability in physically aggressive personality disordered patients: associations with trait and state aggression, and response to fluoxetineAbstract Rationale Characterizing the neuroanatomical basis of serotonergic abnormalities in severe, chronic, impulsive aggression will allow for rational treatment selection, development of novel therapeutics, and biomarkers to identify at-risk individuals.… Read more »
- PT150 blocks the rewarding properties of ethanol and attenuates ethanol-induced reduction of egg laying in Coturnix quailAbstract Rationale Alcohol use disorder (AUD) has been shown to be associated with a dysregulated stress system. Reducing the stress hormone corticosterone (CORT), that binds to glucocorticoid receptors, may attenuate… Read more »
- Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorderAbstract Rationale Chronic cannabis use is associated with impaired cognitive function. Evidence indicates cannabidiol (CBD) might be beneficial for treating cannabis use disorder. CBD may also have pro-cognitive effects; however,… Read more »
- The BDNF Val68Met polymorphism causes a sex specific alcohol preference over social interaction and also acute tolerance to the anxiolytic effects of alcohol, a phenotype driven by malfunction of BDNF in the ventral hippocampus of male miceAbstract Background The brain-derived neurotrophic factor (BDNF) Valine 66 to Methionine human polymorphism results in impaired activity-dependent BDNF release and has been linked to psychiatric disorders including depression and anxiety.… Read more »
- Sex-differences in anxiety, neuroinflammatory markers, and enhanced fear learning following chronic heroin withdrawalAbstract Post-traumatic stress disorder (PTSD) and opioid use disorder (OUD) are comorbid in clinical populations. However, both pre-clinical and clinical studies of these co-occurring disorders have disproportionately represented male subjects,… Read more »
- Dantrolene sodium fails to reverse robust brain hyperthermia induced by MDMA and methamphetamine in ratsAbstract Rationale Hyperthermia induced by psychomotor stimulants may cause leakage of the blood-brain barrier, vasogenic edema, and lethality in extreme cases. Current treatments such as whole-body cooling are only symptomatic… Read more »
- Subjective response to alcohol in young adults with bipolar disorder and recent alcohol use: a within-subject randomized placebo-controlled alcohol administration studyAbstract Limited data exists on mechanisms contributing to elevated risk for alcohol use disorder (AUD) in bipolar disorder. Variation in subjective response to alcohol may relate to alcohol use and… Read more »
- Place conditioning in humans: opportunities for translational researchAbstract Rationale Translational research, especially research that bridges studies with humans and nonhuman species, is critical to advancing our understanding of human disorders such as addiction. This advancement requires reliable… Read more »